Clinical Trials

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Breast Surgical Oncology

ABLATE Trial: Radiofrequency Ablation after breast lumpectomy (eRFA) added to extend intraoperative margins in the treatment of breast cancer

Comparison of preoperative Automated Breast Ultrasound and MRI to determine therapeutic management of newly diagnosed breast cancer patients

Alliance 11202: A randomized phase III trial evaluating the role of axillary lymph node dissection in breast cancer patients who have positive sentinel node disease after neoadjuvant therapy

Breast Medical Oncology

A phase III, randomized clinical trial of standard adjuvant endocrine therapy +/- Chemotherapy in patients with 1-3 positive nodes, hormone receptor-positive and Her-2 negative breast cancer with Recurrence Score (RS) of 25 or less

Abraxane and trastuzumab followed by dose dense doxorubicin and cyclophosphamide as neoadjuvant therapy in invasive breast cancer with low HER-2 expression (1+ or 2+ by immunohistochemistry)

Phase II trial of Lapatinib and RAD-001 for Her-2 positive metastatic breast cancer

Combined Fulvestrant and Anastrazole as Neo-adjuvant endocrine therapy in postmenopausal women with hormone receptor positive invasive breast cancer

Phase II trial of Lapatinib in women with hormone receptor positive (ER and/or PR+) Her-2 negative metastatic breast cancer who have failed prior antihormone therapy

A phase III clinical trial comparing trastuzumab given concurrently with radiation therapy and radiation therapy alone for women with Her-2 positive ductal carcinoma in situ resected by lumpectomy

A randomized, double-blind, placebo controlled, phase II study of BKM120 plus paclitaxel in patient with HER-2 negative inoperable locally advanced or metastatic breast cancer, with or without PI3K pathway activation

A phase III clinical trial comparing the combination of Docetaxel plus cyclophosphamide to anthracycline-based chemotherapy regimens for women with node-positive or high-risk node-negative, Her-2 negative breast cancer

Breast Radiation Oncology

A phase III trial of accelerated whole breast irradiation with hypofraction plus concurrent boost versus standard whole breast irradiation plus sequential boost for early-stage breast cancer

RTOG 1304: A randomized phase III trial evaluating post mastectomy chest wall and regional nodal radiation therapy and post-lumpectomy regional node radiation therapy in patients with positive axillary nodes before neoadjuvant chemotherapy who convert to pathologically negative axillary nodes after neoadjuvant chemotherapy