Severe aortic stenosis is a lethal disease with lower survival rates than some metastatic cancers: as low as 50% at 2 years and 20% at 5 years.
This condition commonly develops with age and occurs when the aortic valve narrows and obstructs blood flow from the heart to the body. As a result, blood pressure in the heart increases, causing weakness and poor function. Severe aortic stenosis frequently leads to heart failure and sudden cardiac death when left untreated. As many as 50% of patients with severe symptoms die within 2 years without appropriate medical intervention.